Decreased vWF:RCo/vWF:Ag ratios in individuals with type 2M vWD. Depicted are the vWF:RCo/vWF:Ag ratios of individuals with low vWF:Ag and normal vWF multimers (Type 1 vWD, ○), type 2M^Milwaukee-1 vWD (▵629-639, •), affected (▪) or unaffected (□) members of Family A and affected (▴) or unaffected (▵) members of Family B studied at The Blood Center of Southeastern Wisconsin. The change in vWF:RCo/vWF:Ag ratios of affected members of Family A and Family B 1 hour after DDAVP therapy is also shown (DDAVP +). The data for the individuals with type 1 vWD and type 2M^Milwaukee-1 vWD has been previously reported.13