Fig. 1.
![Fig. 1. Inhibition of APC and thrombin by PCI in the absence and presence of TM. APC 0.5 nmol/L (A) or thrombin 0.5 nmol/L (B and C) were incubated with 10 (○,•), 25 (□,▪), or 50 (▵,▴) nmol/L PCI, respectively, in the absence (open symbols) or presence (closed symbols) of TM (50 nmol/L rabbit lung [A and B] and 100 nmol/L TM4-6 [C]). At indicated time points, the chromogenic substrates S2366 (1 mmol/L f.c.) or Spectrozyme TH (0.25 mmol/L f.c.) were added to monitor the remaining activity of APC and thrombin, respectively. Please note the difference in x-axis scales in A, B, and C.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/91/5/10.1182_blood.v91.5.1542/3/blod4050201.jpeg?Expires=1724299205&Signature=ROnJb~nG~q2DsdzPySAqsaPKNqHVvkM4ilUlqwfXP6Pwgzq28E8U6Y~hPZVuxrbQsFIC1vTI03GlPfjJlUrZtjWeKld1L8wWiuSjHyPDsCAZT1y1Z9GcRXIgNpvuQ90MBykFzWEMEhJprRDguJZ2zAhniDVjfEIsVAkCO2l4B1ydER9XuTssm~N~-3Yltxnr8sXpN1JoL6nr4A-hjteNRjjrhBQmMRanJmI~juMaF5oYR7KnQYrjrFIY2F2eCWKZ9Q9JBxxAK1EOFABqOnj3peoq2SzreVMJVJMF4Ddj8vBj2lzPWhZxuQ0vjCovXffaSmBUjWGO37AoOJBfegFwnA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Inhibition of APC and thrombin by PCI in the absence and presence of TM. APC 0.5 nmol/L (A) or thrombin 0.5 nmol/L (B and C) were incubated with 10 (○,•), 25 (□,▪), or 50 (▵,▴) nmol/L PCI, respectively, in the absence (open symbols) or presence (closed symbols) of TM (50 nmol/L rabbit lung [A and B] and 100 nmol/L TM4-6 [C]). At indicated time points, the chromogenic substrates S2366 (1 mmol/L f.c.) or Spectrozyme TH (0.25 mmol/L f.c.) were added to monitor the remaining activity of APC and thrombin, respectively. Please note the difference in x-axis scales in A, B, and C.
