American Society of Hematology

Fig. 6.

$Fig. 6. Deletion of the carboxy-terminal 44 amino acids of c-kit reduces proliferation in response to FK1012 and AP1510. MTT assays were performed on three Ba/F3 clones expressing F3c-kit388, in which the carboxy terminal 44 amino acids of the c-kit receptor were deleted. Each clone responded to both FK1012 (upper panel) and AP1510 (lower panel), however, the level of proliferation was less than in clones expressing F3c-kit432 (Fig 2). Results are plotted as a fraction of the OD570-630 value measured from the same cells cultured in 5% WEHI conditioned medium. A second experiment yielded very similar results.$

Deletion of the carboxy-terminal 44 amino acids of c-kit reduces proliferation in response to FK1012 and AP1510. MTT assays were performed on three Ba/F3 clones expressing F3c-kit388, in which the carboxy terminal 44 amino acids of the c-kit receptor were deleted. Each clone responded to both FK1012 (upper panel) and AP1510 (lower panel), however, the level of proliferation was less than in clones expressing F3c-kit432 (Fig 2). Results are plotted as a fraction of the OD570-630 value measured from the same cells cultured in 5% WEHI conditioned medium. A second experiment yielded very similar results.

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