Fig. 3.
![Fig. 3. Electron micrographs of frozen thin sections from human BM labeled by a biotinylated sCI-MPR probe. The Man 6-P GP are visualized with streptavidin 10 nm. (a) Early immature granulocytic cell of the BM. (b) The Golgi complex (GC) of an immature cell is labeled for Man 6-P GP. (c and d) In this immature neutrophil from BM (portion of the promyelocyte or an early myelocyte from [a]), the highest levels of Man 6-P GP are found within the newly formed azurophilic granules (Ag), some of which have retained their density (Ag′) as in (c), while others appear extracted (d) but retain immunolabel. At intermediate stages of maturation (myelocytes), an MLC is first observed (Inset, [d]).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/91/3/10.1182_blood.v91.3.1044/3/blod4033603.jpeg?Expires=1725169827&Signature=29NmmmhJPXt7OSFO2hHDdBkju2-UHYqdllvgxLhuuEfIxpys4XhN9pEhJgrJ9OM8uTZOlF6~QHZlEE7iVQ~RFmgy6njxplc~zSl-IUKnmCK3GCZuyrDs3DcduJrGW~KO5qszBV39eJGysxKQHYd4r124rTWXFd-EGyhl223rczR2RL0BwSn0foykhnBtTw~URhUkcKcZuaqG2hf8r-17TdtqCfIYqtMA1x9CoJscqzd~l84sHGNGcCGk6ekhbg~5c9K7ikt58RMwS3N0ja2jV99qHR9lf7X~Qa-dLiF2BvynmHbVakfE7G5iNvxHFHRR49ICldc9yoP1EIQKEeNYWA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Electron micrographs of frozen thin sections from human BM labeled by a biotinylated sCI-MPR probe. The Man 6-P GP are visualized with streptavidin 10 nm. (a) Early immature granulocytic cell of the BM. (b) The Golgi complex (GC) of an immature cell is labeled for Man 6-P GP. (c and d) In this immature neutrophil from BM (portion of the promyelocyte or an early myelocyte from [a]), the highest levels of Man 6-P GP are found within the newly formed azurophilic granules (Ag), some of which have retained their density (Ag′) as in (c), while others appear extracted (d) but retain immunolabel. At intermediate stages of maturation (myelocytes), an MLC is first observed (Inset, [d]).
