Photomicrographs of gross pathology of ligneous lesions in Plg^−/− mice, showing mild and severe manifestations. (A) Thickened eyelid representing an early or mild lesion. Note that the observed cataract formed postmortem. (B) Stromal haze and epithelial defect; (C) pedunculated lesion in the upper lid, with ulceration and hemorrhage in the lower lid; (D) plaque extending above the corneal surface; (E) neovascularization of the cornea extending from the limbus into the plaque (arrows); and (F) corneal neovascularization around the circumference of a plaque (arrows).