Effect of thrombin on the inhibitory activities of rTFPI toward factor Xa and TF/factor VIIa. The reaction mixture as described in Fig 1 was subjected to the analysis of TFPI inhibitory activity. The residual TFPI activity was expressed as the percent relative to that of intact rTFPI. (•), Inhibitory activity toward factor Xa; (○), inhibitory activity toward TF/factor VIIa.