Immunolocalization of GM-CSF receptors in benign and malignant human prostate tissues. Consecutive tissue sections were incubated with anti-α (left panel) or anti-β–subunit (right panel) antibodies. (A) Low to undetectable levels in the epithelial cells of the normal gland. (B) Moderate levels of expression in the epithelial cells of benign prostatic hyperplasia. (C) Increased immunoreactive pattern in a primary tumor. (D) High levels of expression in a lymph node and a bone (E) metastases. Stars in bone metastases images indicate bone location. Two different magnifications of each immunostained tissue section are shown (160× and 400×).