Exposure of FBG and fibrin-specific epitopes on A549 lung cell-derived FBG and plasma FBG deposited in the ECM of fibroblasts. Immunofluorescent staining was performed using MoAbs specific for FPA (A, D, and G), FPB (B, E, and H), and fibrin β15-21 (C, F, and I). HFFs were overlaid with conditioned media from A549 cells (A through C), with complete media containing purified plasma FBG (D through F ), or with complete media with no added ligand. The bar in (I) represents 10 μm.