Glyburide inhibits the secretion of IL-1β from mouse peritoneal macrophages without affecting the release of IL-1α, TNFα, or IL-6. (A) Dose-dependent inhibition of IL-1β release from macrophage monolayers as assessed by ELISA. Results are averaged from four individual assays and expressed as a percentage of release in the absence of the drug. Absolute values in picograms per milliliter are indicated. (B) Comparative effect of 100 μmol/L glyburide on the secretion of IL-1β IL-1α, TNFα, or IL-6. Results (averaged from 6 experiments for IL-1β and TNFα and from 4 for IL-1α and IL-6) are expressed as a percentage of the amount released in the absence of drug.