Fig. 6.
![Fig. 6. The effects of FcγRI antagonists on rhIFN-γ–enhanced bacterial ingestion by neutrophils. The graph shows the effect of anti-FcγRI MoAb (197) and F(ab′)2 (32.2), and control murine IgG2a (mIgG2a) and murine F(ab′)2 [mF(ab′)2 ] on phagocytosis of HI-PHS–opsonized S aureus-BODIPY BioParticles by neutrophils. The mean MFI of neutrophils obtained from two different study subjects (□) before in vivo rhIFN-γ administration (0.05 mg/m2/dose SC daily for 2 days) and (▪) 48 hours after the initiation of in vivo rhIFN-γ treatment are depicted. Asterisks indicate statistically significant inhibition by the MoAb or F(ab′)2 when compared with the corresponding 48-hour control in which no MoAb or F(ab′)2 was present (Student's t-test, P < .05).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/90/8/10.1182_blood.v90.8.3187/4/bl_0003f6.jpeg?Expires=1724262061&Signature=bUQOZj0WM724vUTEHybW1kOeUxGq8KClULrwK1MZQZXCe7xFa~PlBa5AkrYzhLu1tYEoVt5QH94RdA4arGTDJXhbcNMIE1qzZ~CtNII7h8mNSpf8wiVNRgtPuNbtVWR4MUV7VQdilhNvkkbxFfn79nL6FSYul86O6R9WxNq20V0tsKNsn2NDOBpSzBd6Tl9lpqV8xqxg1iGKNgC5UfIBT6L6y2bVI9~uSCi5UFJVtOVaRS5si3vBG~bLPoEd1uDRgtWY0qBmbl1F~JRyexx-ZwqnPLyITTZMudTvS42~ADQQV7P3XdUn8P2CRQoekYAlmvxspbQPfrmbi9rFnxurOw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The effects of FcγRI antagonists on rhIFN-γ–enhanced bacterial ingestion by neutrophils. The graph shows the effect of anti-FcγRI MoAb (197) and F(ab′)2 (32.2), and control murine IgG2a (mIgG2a) and murine F(ab′)2 [mF(ab′)2 ] on phagocytosis of HI-PHS–opsonized S aureus-BODIPY BioParticles by neutrophils. The mean MFI of neutrophils obtained from two different study subjects (□) before in vivo rhIFN-γ administration (0.05 mg/m2/dose SC daily for 2 days) and (▪) 48 hours after the initiation of in vivo rhIFN-γ treatment are depicted. Asterisks indicate statistically significant inhibition by the MoAb or F(ab′)2 when compared with the corresponding 48-hour control in which no MoAb or F(ab′)2 was present (Student's t-test, P < .05).
