Erythrophagocytosis in myelomatous pleural effusion. A 59-year old woman with advanced multiple myeloma (IgG,κ) and ischemic heart disease presented with congestive heart failure and pancytopenia. A pleural effusion was noted on initial examination and persisted despite diuresis. A diagnostic thoracentesis was performed. The cytospin preparation demonstrated erythrophagocytosis by dysplastic plasma cells and macrophages. (Wright's stain; original magnification ×1,000.) (Courtesy of Larry L. Frase, MD, Joseph Newman, PhD, Martin L. Hurst, MD, and Marvin J. Stone, MD, Baylor-Sammons Cancer Center, Dallas, TX 75246.)