(Upper part) Localization of the polymorphic sites and of primers used to define haplotypes in exon 13 of the FV gene. H, HinfI; E, EcoRI; T, Taq I; R, Rsa I. (Lower part) Single (T and R) and combined (T/R) restriction of the large fragment (2,099 bp) for the assignment of linkage between polymorphisms in a doubly heterozygous subject (a, Indian no. 5); b, homozygous subject used as control (Indian no. 33 in Table 1). The restriction map for each allele is reported above the gel. The band corresponding to the 208/9-bp fragments is not shown. M, molecular weight marker. Fragment size is given in basepairs.