Kinetics of fMet-Leu-Phe– and TNF-α–induced VEGF (A) and lactoferrin (B) secretion in adherent human neutrophils. Neutrophils (10⁷/mL) were incubated with (▤) 10⁻⁷ mol/L of fMet-Leu-Phe and (▪) 20 ng/mL of TNF-α for the indicated periods of times at 37°C. Secreted VEGF and lactoferrin were assessed by specific ELISAs. Each point represents the mean ± SEM of five different determinations. * P < .05 v unstimulated neutrophils.