Effect of a soluble TNFα receptor (p55)-IgG fusion protein (TNFR-IgG) on the TNFα-induced ¹¹¹In-eosinophil accumulation in rat skin. Using a 4-hour in vivo test period, the graph shows responses to TNFα alone (10⁻¹¹ mol/site; ▪), TNFα coinjected with TNFR-IgG (3 to 30 μg/site; ▨), TNFR-IgG alone (30 μg/site; ), and Tyrode (□). Results are the mean ± SEM for n = 5 animals. Asterisks indicate a significant difference from sites injected with TNFα alone (*P < .05).