Effect of TNFα on local eosinophil accumulation as measured by EPO activity in skin sites. The graph shows EPO activity in skin sites injected with TNFα (10⁻¹¹ mol/site) or Tyrode, using a 4-hour or 1-hour measurement period. Results represent the number of eosinophils per skin site ± SEM (n = 3). A significant difference over Tyrode injected sites is indicated by **P < .01.