(A) Pedigree of case A-98. The splice site mutation exon 14:11397 (G → A) (solid symbols) and exon 10: L395M (9988 C → A) (hatched symbols), a mutation close to His393. (B) Clotting parameters and genotypes. (C) Genomic sequence and derived amino acid sequence of wild-type and mutated exon 14.11 (D) Automated fluorescence sequence for the reverse wild-type sequence around L395. (E) Automated fluorescence sequence for the reverse mutated sequence around L395M.