The structure of high molecular weight kininogen. An amino acid sequence diagram of high molecular weight kininogen. A circle with thin vertical lines represents a papain inhibitory domain. A circle with thin horizontal lines represents a calpain inhibitory domain. A circle with a solid background represents a cell surface binding domain. A circle with thick vertical lines represents overlapping papain inhibitory activity and cell surface binding activity. A circle with thick horizontal lines represents bradykinin. A circle with a blank backround represents the factor XI binding domain. A circle with a shaded background represents overlapping prekallikrein and factor XI binding domain.