Effect of IL-12 pretreatment (200 ng/mouse, IP; at −14 days) on LPS (10 μg/mouse, daily, IP)-induced decrease in body weight (A) and food intake (B). Body weight is expressed as mean ± SD (n = 5). Food intake was evaluated per cage with five mice. (□), Vehicle; (♦), vehicle/LPS; (○), IL-12/LPS.