Effect of IL-12 (200 ng/mouse), IL-12 + anti–IFN-γ (0.2 mL/mouse, IP; 2 hours before IL-12) or IL-12 + anti–IL-10 (0.2 mL/mouse, IP; 2 hours before IL-12), administered on day −14, on the decrease in body weight (A) and food intake (B) induced by chronic IL-12. Body weight is expressed as mean ± SD (n = 5). Food intake was evaluated per cage with five mice. (□), Vehicle; (♦), IL-12; (•), IL-12/IL-12; (▵), anti–IFN-γ + IL-12/IL-12; (*), anti–IL-10 + IL-12/IL-12.