Superimposed recordings of carotid artery blood flow in representative rabbits treated with saline or rTFAA. Blood flow through the carotid artery of anesthetized rabbits was monitored with an ultrasonic flow probe (Transonics). The following procedures were performed at the times designated by the symbols in the figure: () IV bolus administration of test compounds, (▾) embolectomy catheter inserted, (▴) embolectomy catheter removed, (✖) cuticle bleeding time determined, (+) blood sample collected for APTT and PT determination. The rapid changes in blood flow that occur between catheter insertion and catheter removal are the result of inflating and deflating the balloon between six repeated passes through a 2-cm segment of artery.