Plasma levels of prothrombin fragment F1 + 2 (top panel), activated factor VII (FVIIa) (middle panel), and activated factor XII (FXIIa) (bottom panel) in 30 normal subjects (□), in 19 patients with HAE during remission (R), in five patients with HAE during acute attacks (AA) (type I = ○; type II = •) and in six patients with AAE. AAE patients (individuals identified by different symbols) were observed during R and three of them also during seven episodes of AA. Horizontal lines represent medians.