Aspects of the EBV genome and C promoter regulation. (A) The linear EBV genome. (B) CpG sites upstream of the C promoter whose methylation status was monitored by genomic sequencing (nos. 1 through 9). (C) The EBNA-2 responsive region of the C promoter. The schematic illustrates the nucleotides protected by CBF1 and CBF2 in DNAse protection assays and the interaction of EBNA-2 with CBF1.