Fig. 5.
![Fig. 5. IL-4 markedly inhibits apoptosis of CLL B cells compared with normal B cells (A). B cells from 11 CLL patients or normal donors (n = 7) were cultured alone (▪) or with 10 ng/mL IL-4 (▨) for 48 hours. Apoptosis was assayed by TUNEL and the percentage of apoptotic cells is shown for each patient and for normals. (B) Percent change in spontaneous apoptosis upon addition of IL-4 calculated as [(percent apoptosis with IL-4/spontaneous apoptosis)] × 100% (P < .005).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/89/3/10.1182_blood.v89.3.941/8/bl_0010f5.jpeg?Expires=1722403234&Signature=l27FK9HrK1CbGVk9tW6syZKPPf1mkHvWaxC4vkhIJ3Tv0X61vNcvj4nOT-e2bdDi4bS~b~i1rluwEATwSNxZ0A6cth4xrV82QNOY5AZVL1i9GuHIkILIZmCfDiDDhBxh2Qt85~tXY4LdAPZD-F~l~pW4MSUYJBVfx9GqVwR59ZC8jXSFN0z2DUuLMDCBQHH13m0Nnf7sstSND8fCK9v17GBP1aXW46Vfws8nJX7dtszKzqw1vdc8RMK-V5eGDlH9-RFG7qd91OIK20jRq6fT4QFDCAba9LXJ6OMdcNVJDGHQ2BGmJVRQcbpeopo-IMUEmwJu2gBy6T90fjdtcGDWiA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
IL-4 markedly inhibits apoptosis of CLL B cells compared with normal B cells (A). B cells from 11 CLL patients or normal donors (n = 7) were cultured alone (▪) or with 10 ng/mL IL-4 (▨) for 48 hours. Apoptosis was assayed by TUNEL and the percentage of apoptotic cells is shown for each patient and for normals. (B) Percent change in spontaneous apoptosis upon addition of IL-4 calculated as [(percent apoptosis with IL-4/spontaneous apoptosis)] × 100% (P < .005).
