Fig. 2.
![Fig. 2. CLL B cells are resistant to TGF-β–mediated apoptosis. (A) CLL B cells from 13 patients or normal B cells (n = 7) were cultured alone (▪) or with 5 ng/mL TGF-β (▨) for 48 hours. Apoptosis was assayed by TUNEL, and the percentage of apoptotic cells is shown for each patient and for normals. (B) Percent change in spontaneous apoptosis upon addition of TGF-β is calculated as [(percent apoptosis with TGF-β/spontaneous apoptosis)] × 100% (P < .002).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/89/3/10.1182_blood.v89.3.941/8/bl_0010f2.jpeg?Expires=1722403737&Signature=t0qNDB1jnyPuoqegxSefD4JKW9sZCYH-~Hj-wkmLqSYF1NObiwcXOQcj6FmhRVNUrCRSa~dMmmka79jKaPNvZPNT20pKBFFOZ8KBR~ZexPsSMlsv3d2QiJuQFxh9wE7LzfHB1GJYOQRdjSmdFEjxnLHKZ~yYZ2ZyYY-nM2D6GQe4PfXtK-XZRVjT4tWN7vreJ7aopvi9c4zANELZpNtQurxPFIhJ3dWMAFVMF~ng4zNpzbiXcW~o7EHEXELAW4zg1YYXp537f0OcvZPIHzyDbB4QwnWTg9Jwl19Dzfp43g7zWD9Smpa52Tj2KYkrDzbuDwIlmuk8uiCStOf3HmEY6A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CLL B cells are resistant to TGF-β–mediated apoptosis. (A) CLL B cells from 13 patients or normal B cells (n = 7) were cultured alone (▪) or with 5 ng/mL TGF-β (▨) for 48 hours. Apoptosis was assayed by TUNEL, and the percentage of apoptotic cells is shown for each patient and for normals. (B) Percent change in spontaneous apoptosis upon addition of TGF-β is calculated as [(percent apoptosis with TGF-β/spontaneous apoptosis)] × 100% (P < .002).
