Whole blood from healthy individuals (controls, n = 4) and critically ill patients (n = 4) was incubated with SAC (0.075% wt/vol) in the presence or absence of either rhIFN-γ (10 ng/mL) (A, B) or rh IL-12 p70 (5 ng/mL) (C) for 24 hours. Plasma levels of IL-12 p40 (A), p70 (B), and IFN-γ (C) were determined using specific ELISA. Data are presented as mean ± SEM; *P <. 05 SAC versus SAC + rhIFN-γ or SAC + rhIL-12 p70; #P < .05 patient versus control.