Three different aspects of brain imaging in HLH patients. (A) CT scan of a 3-month-old baby showing a large subdural effusion, several necrotic areas and hypodensities of the white matter. (B) Brain magnetic resonance of a 14-month-old boy showing large confluent areas of hypersignal in T2-weighted images. (C) Large symmetrical necrotic areas of cerebellar white matter in a 4¹/₂-year-old girl (MRI).