Purified transgenic platelets exhibit normal aggregation response. (A) c-mpl ligand enhances aggregation response in nontransgenic mice. Representative aggregation response to 1 μg/mL collagen with or without 1 μg/mL exogenously added rHuMGDF. (B) Comparison of collagen-induced aggregation response between AM107 and control littermates. n = 3. Data are the mean ± SD. AC₅₀ , P = .89. (C) Comparison of ADP-induced aggregation response between AM107 and control littermates. n = 4. AC₅₀ , P = .41.