Fig. 1.
Expression and effects of human c-mpl ligand cDNA in transgenic mice. (A) Serum levels of human c-mpl ligand protein in transgenic lines. #Less than 10 pg/mL. n ≥ 4. (B) Platelet count in AM107 and AM1636 lines and control littermates aged 6 to 12 weeks. n ≥ 10. *P < .001 v control. (C) Megakaryocyte number in bone marrow and spleen sections of AM107 and control littermates. Sections from 3 animals were used for each determination. *P < .001. (D) MEG-CFC numbers in bone marrow and spleen of AM107 and control littermates. Data are presented as % control level (control level = 85 ± 8 per 105 bone marrow cells and 7 ± 2 per 106 spleen cells). n = 3. *P < .01.
