RANTES production by Tc1 (○) and Tc2 (•) clones derived from PBMC of HIV-seronegative and HIV-seropositive patients. Supernatants of 90 randomly selected CD8⁺ T-cell clones (26 Tc1 and 12 Tc2 generated from PBMC of HIV-seronegative subjects and 31 Tc1 and 21 Tc2 from PBMC of HIV-seropositive individuals), obtained as described in the legend to Fig 1, were assessed for the content of RANTES, as described in Materials and Methods.