Representative SSCP analysis of genomic DNA from B-PLL showing absence of mutations in exons 4 and 10 of p53. SSCP was performed as described in the Materials and Methods. Abnormally migrating conformers in control DNAs are indicated with arrows. (A) SSCP of exon 4. Lane C, control DNA with known missense mutation at codon 102 of p53. Lanes 1 through 5, DNA from individual B-PLL cases. (B) SSCP of exon 10. Lane C, control DNA with a known missense mutation at codon 336 of p53. Lanes 1 through 7, DNA from individual B-PLL cases.