Fig. 1.
Fig. 1. A point mutation at codon 890 in the ligand-binding domain of PML-RARα. (A) Schematic structure of PML-RARα, showing the approximate positions of two primers used in RT-PCR to amplify the RARα part of PML-RARα (PRα ΔA). (B) Sequencing autoradiogram shows the T → C conversion at PML-RARα codon 890, which results in the exchange of leucine to proline.

A point mutation at codon 890 in the ligand-binding domain of PML-RARα. (A) Schematic structure of PML-RARα, showing the approximate positions of two primers used in RT-PCR to amplify the RARα part of PML-RARα (PRα ΔA). (B) Sequencing autoradiogram shows the T → C conversion at PML-RARα codon 890, which results in the exchange of leucine to proline.

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