In vivo multilineage differentiation by Lin⁻ c-Kit⁺ Sca-1⁺ TIE⁺ (A) and Lin⁻ c-Kit⁺ Sca-1⁺ TEK⁺ cells (B). Two hundred cells of each fraction from Ly-5.1 donor mice were injected intravenously into lethally irradiated Ly-5.2 recipient mice. Six weeks after transplantation, donor-derived (Ly-5.1) cells were detected in the peripheral blood of recipient mice and phenotyped by two-color FACS analysis. These are the representative data of the transplantation experiment of 8 mice in each group.