Cytotoxic activity of gld/gld CTLs. MLR-produced CTLs (H-2^b anti–H-2^d) from wild-type (+/+), +/gld (+/g), and gld/gld (g/g) mouse splenocytes tested against TA3 lymphoma cells at a fixed E:T ratio of 10:1 in ⁵¹Cr release (A) and ¹²⁵IUdR release (B) assays. Both gld/+ and gld/gld CTLs have no detectable defect in the ability to induce ⁵¹Cr or ¹²⁵I-labeled DNA release at all time points tested. Error bars represent the range of values at each point. These are representative data from one of three similar experiments.