Family relationship of germline individuals in the protein S–deficient kindred currently under investigation. Additional untested relatives are shown if they were siblings or ancestors of tested family members. All protein S–deficient individuals tested had the Gly295Val mutation. Protein S deficiency subclassification for nonanticoagulated affected family members is as used for genetic analysis (type I, III, and I/III phenotypes). The 3 individuals selected for genetic analysis are indicated with an asterisk (IV-30, V-34, and VI-18). Investigated family members who had venous thrombosis are indicated with a diamond. The single family member who was heterozygous for the factor V Arg506Gln mutation is indicated with a cross.