Fig. 4.
Autoradiographs showing the in vivo binding and degradation of 125I-rmTPO by platelets and spleen tissue following IV administration of 125I-rmTPO. Mice received a single IV bolus injection of 125I-rmTPO or 125I-rmTPO + 10 μg rmTPO and were killed 3 hours later. (A) Citrated blood, (B) spleens, and plasma were obtained and processed. These samples were then analyzed by SDS-PAGE. Approximate MW were determined from MW standards run on the same gel.
