Southern blot analysis of genomic DNA from two patients carrying the therapy-related inv(11). Genomic DNA samples from two inv(11) patients (Pt1, patient 1; Pt2, patient 2), as well as control cell lines (Ct1, Namalwa; Ct2, C498) were digested with EcoRI or BamHI. Rearranged bands are indicated by arrowheads. Hybridization of three probes, PE84S1 (A), DX-LM3 (B), and NP-FRG10 (C), is shown. kb, kilobases.