Noninferiority plot comparing the difference in percentage of transfusion-treatment periods with WHO grades 2, 3, and 4 bleeding in the intervention and control arms. The point estimates of the difference in percentage points and their 95% CIs are displayed for the ITT analysis and the per-protocol analysis. The dashed vertical line shows the predefined margin of 12.5 percentage points. For the ITT analysis, the noninferiority criterion is met. For the per-protocol analysis, the 95% CI exceeds the margin of 12.5% points, and the noninferiority criterion is not satisfied.