Fig. 6.
Pathophysiologic model of megaloblastic anemia based on apoptosis at the basophilic and polychromatophilic erythroblast stages that produce large reticulocytes. Cells appear as stained with 3,3′-dimethoxybenzidine and hematoxylin. Apoptotic cells are indicated by condensed and fragmented nuclei. See text for description.