Kaplan-Meier estimate of PFS according to a prognostic score based on the combination of MH and TLG at baseline, with shadows indicating 95% CIs. Low-risk patients are defined by the presence of both low MH and low TLG at presentation. The intermediate-risk group comprises the patients with either low MH and high TLG or high MH and low TLG. High-risk patients are defined by the presence of both high MH and high TLG. The trend test for the overall model was statistically significant, as well as the comparison (log-rank test) of the individual curves (low risk vs intermediate risk, P = .0286; low risk vs high risk, P < .0001; intermediate risk vs high risk, P < .0001).