Targeted mutational landscape of DTFL and LSTFL. (A) Mutation plot for DTFL and LSTFL, depicting only genes that were mutated in at least 3 samples and captured by both bait sets. Mutation type and BCL2 status are color coded. BCL2 rearrangement refers to FISH testing. BCL2 IHC refers to immunohistochemistry. (B) Mutation frequencies of recurrently mutated genes in DTFL, LSTFL, and ASTFL cohorts. The bar plot shows mutation frequencies for all genes mutated in >10% of any of the 3 cohorts. *P < .05, **P < .01 for FDR-corrected Fisher’s exact test. (C) Fraction of cases with monoallelic or multiple KMT2D mutations in DTFL, LSTFL, and ASTFL cohorts. P values indicate result of Fisher’s exact test.