Participant screening and enrollment in the SIT Trial. Four density maps were created: (1) 286 children with SCA and no history of stroke who had SCIs adjudicated by the SIT neuroradiology committee after screening MRI; (2) 13 children with SCA and overt infarct who were excluded from the cohort of adjudicated SCIs; (3) baseline MRI; and (4) 3-year follow-up MRI from 20 children with SCA and no history of stroke who had SCIs adjudicated and who had recurrent overt or silent infarct by 3-year follow-up.