TAFI deficiency does not cause prolonged tail bleeding in HA mice. (A) Tail bleeding in WT C57Bl/6J, TAFI^−/− C57Bl/6J, and FVIII^−/− BALB/c mice with or without anti-FVIII antibody (0.25 mg/kg; n = 8-12). Bleeding was determined by measuring the mouse weight-normalized blood loss (µL/g) after tail resection for 20 minutes. (B) Bleeding determined by Hct at 24 hours after tail resection in WT C57Bl/6J, TAFI^−/− C57Bl/6J, and FVIII^−/− BALB/c mice, with or without anti-FVIII antibody (0.25 mg/kg), that survived 24 hours after tail resection. (C) Survival rate after tail resection of WT C57Bl/6J (n = 12; filled and open down triangles) or TAFI^−/− C57Bl/6J (n = 12; filled and open up triangles) with (open triangles) or without (filled triangles) anti-FVIII antibody (0.25 mg/kg) and FVIII^−/− BALB/c mice (n = 8; open circles). For the survival experiment, the log-rank (Mantel-Cox) test was used to compare experimental mice with WT mice after tail clip. Kruskal-Wallis test was used followed by Dunn’s post hoc multiple comparison test to compare experimental mice. *P < .05, **P < .01, ***P < .001. ns, not significant.