Construction of the 3-miRNA classifier. (A) Hierarchical clustering of the 123 differently expressed miRNAs in the discovery cohort of 82 patients with MF (lesional sample) and the 20 age- and sex-matched healthy controls (normal control sample), using Euclidean distance with average linkage clustering. Each row represents a single miRNA, and each column represents an individual sample. Colors indicate the normalized expression level from low (blue colors) to high (red colors) expression on a log scale from 4 to −6. (B) LASSO coefficient profiles of the 10 miRNAs most predictive of disease progression. miR, microRNA.