Figure 5.
GDC-0853 lacks inhibition of EGFR and ITK in cells. (A) The A549 lung cancer cell line was treated with varying concentrations of BTK inhibitor to determine the effect on EGFR activation. (B) T-cell activation in healthy donor T cells following treatment with 1 µM BTK inhibitor before T-cell receptor stimulation with anti-CD3 and anti-CD28.