GDC-0853 abrogates important cellular functions including CLL activation and migration. (A) Activation of CLL cells 48 hours following 3.2 µM CpG stimulation as determined by CD86 expression via flow cytometry (N = 22). MFI results were normalized to untreated paired samples. (B) Migration of CLL cells toward the chemokine CXCL12 in the presence of DMSO, 1 µM GDC-0853, or 1 µM ibrutinib (N = 11). *P ≤ .05; **P < .01. MFI, mean fluorescence intensity.