American Society of Hematology

Figure 4.

$Figure 4. A fraction of Asxl1Y588XTg developed MPN. (A) Assessment of platelet (PLT) levels in PB from Asxl1Y588XTg mice (n = 39) and WT littermates (n = 16) at various ages. (B) May-Grünwald-Giemsa–stained PB smears, cytospins of BM and spleens from representative WT (top), and Asxl1Y588XTg mice with MPN (bottom) are shown. Bar represents 10 µm. (C) H&E–stained sections of femurs and spleens from representative WT (top) and Asxl1Y588XTg mice with MPN (bottom) are shown. Bars represent 1 mm, 10 μm, or 100 μm. (D) Representative flow cytometric analysis of CD41+/CD61+ cells in BM and spleen cells of WT littermate (left) and Asxl1Y588XTg mice with MPN (right).$

A fraction of Asxl1^Y588XTg developed MPN. (A) Assessment of platelet (PLT) levels in PB from Asxl1^Y588XTg mice (n = 39) and WT littermates (n = 16) at various ages. (B) May-Grünwald-Giemsa–stained PB smears, cytospins of BM and spleens from representative WT (top), and Asxl1^Y588XTg mice with MPN (bottom) are shown. Bar represents 10 µm. (C) H&E–stained sections of femurs and spleens from representative WT (top) and Asxl1^Y588XTg mice with MPN (bottom) are shown. Bars represent 1 mm, 10 μm, or 100 μm. (D) Representative flow cytometric analysis of CD41⁺/CD61⁺ cells in BM and spleen cells of WT littermate (left) and Asxl1^Y588XTg mice with MPN (right).

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