Mechanisms of novel hemophilia therapies. (A) Normal hemostatic balance tipped in favor of bleeding, for example, (B) in hemophilia A from lack of coagulation FVIII. (C) One approach to improve hemostatic balance in hemophilia is to add additional procoagulants; (D) another approach is to remove or inhibit anticoagulants. Adapted from Willyard.⁶⁴