Figure 4.
HO-1 suppression rescues erythroid cell differentiation, suppresses erythroblast expansion, and reduces Fam132b expression in the bone marrow of Th3/+mice. (A) Representative dot plots of flow cytometry analysis of CD71 (y-axis) and Ter119 (x-axis) expression and its quantification in the bone marrow and the spleen from Wt and Th3/+ mice injected with either PBS or SnPP (n = 3). (B) Flow cytometry analysis of Ter119− and Ter119+ cells present in the bone marrow (n = 3) and the spleen (n = 5) of Wt and Th3/+ mice injected with either PBS or SnPP. (C) qRT-PCR analysis of Fam132b mRNA expression in bone marrow isolated from Wt and Th3/+ mice injected with either PBS or SnPP. The results are presented as fold change relative to Wt + PBS samples (n = 3). *P < .05, ***P < .001.

HO-1 suppression rescues erythroid cell differentiation, suppresses erythroblast expansion, and reduces Fam132b expression in the bone marrow of Th3/+mice. (A) Representative dot plots of flow cytometry analysis of CD71 (y-axis) and Ter119 (x-axis) expression and its quantification in the bone marrow and the spleen from Wt and Th3/+ mice injected with either PBS or SnPP (n = 3). (B) Flow cytometry analysis of Ter119− and Ter119+ cells present in the bone marrow (n = 3) and the spleen (n = 5) of Wt and Th3/+ mice injected with either PBS or SnPP. (C) qRT-PCR analysis of Fam132b mRNA expression in bone marrow isolated from Wt and Th3/+ mice injected with either PBS or SnPP. The results are presented as fold change relative to Wt + PBS samples (n = 3). *P < .05, ***P < .001.

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