Outcomes in R/R patients with chromosomal abnormalities detected by FISH and with CK. (A) Best response by high-risk genetic features. (B) PFS by chromosomal abnormalities detected by FISH. (C) OS by chromosomal abnormalities detected by FISH. (D) PFS by CK. (E) OS by CK. Survival analysis by FISH cytogenetic subgroups was based on Döhner hierarchy categorization.