Clinical features of patients with non-HFE and HFE-related HH. The presence or absence of the clinical features (A) cardiac involvement, (B) hypogonadism, (C) diabetes/hyperglycemia, (D) skin pigmentation, (E) arthritis/arthropathy, and (F) liver fibrosis were determined in all patients with a genetic diagnosis of HJV-, HAMP-, TFR2-, or HFE-related HH. Patients with HFE HH have been divided into probands and nonprobands. Differences in the prevalence of clinical features between the HFE (proband) group and all other groups were compared using Fisher’s exact test. Statistically significant differences are denoted as ****P < .0001, ***P < .001, **P < .01, and *P < .05. For statistical analyses in (F), liver fibrosis and cirrhosis were combined. For the statistical analyses denoted by asterisks above the boxes, patients with missing data for a particular clinical feature were assumed to not have that clinical feature. For the statistical analyses denoted by asterisks inside the boxes, patients with missing data were excluded.